李远友

姓名:李远友

职务:水生动物营养与饲料科学系教师

职称:教授

联系方式:yyli16@scau.edu.cn

l个人简介

李远友，男，中山大学博士，日本东京大学博士后，华南农业大学海洋学院二级教授、博士生导师。曾任海洋学院党委委员，水生动物营养与饲料科学系主任；汕头大学理学院副院长，海洋生物研究所所长兼广东省海洋生物技术重点实验室主任等职。

主要研究方向为水产动物营养与饲料学，重点关注脂质营养。已主持承担包括国家自然科学基金重点国际合作研究项目及面上项目、国家海水鱼产业技术体系岗位科学家项目等在内的省部级以上科研课题30余项，其中国家基金9 项。在PNAS、Progress in Lipid Research等国内外学术期刊上发表论文200余篇，其中 SCI 论文120多篇；获省级科技奖3项，大北农科技奖1项；出版《鱼类脂肪酸精准营养的理论与应用实践》专著，参编著作3 部；获授权发明专利13件，制订广东省农业地方标准5项，向世界基因库NCBI登记新基因序列48个。在鱼类脂肪酸精准营养的基础理论与应用研究方面取得系列创新性重要成果，主要涉及鱼类的必需脂肪酸需求特性、高不饱和脂肪酸合成代谢调控机制、脂肪酸精准营养需求及低鱼油低鱼粉高效环保配合饲料研发等。相关成果不仅奠定本团队在鱼类脂肪酸分子营养学研究领域的国际领先地位，也为提高饲料油脂的科学利用水平、破解我国水产饲料对鱼油依赖性过强的“卡脖子”问题提供有效解决方案和坚实理论与技术支撑。

l学习和工作经历

1982.9－1989.6：湖南师范大学生命科学学院本科生，硕士研究生（导师：刘筠院士）。

1989.6－1995.8：湖南农业大学动物科技学院水产系教师，党支部书记。

1995.9－1998.6：中山大学生命科学学院博士生（导师：林浩然院士）。

1998.7－2016.12：汕头大学海洋生物研究所/广东省海洋生物技术重点实验室教师，先后获评（聘）副研究员（1999）、硕导（2001），教授（2004），博导、校特聘教授（2006—），二级教授（2011—），所长兼省重点实验室主任（2007-2016），理学院副院长（2010-2014）。

2000.11－2002.11：日本东京大学海洋研究所博士后，特聘研究员。

2016.12：以“高端-拔尖”人才身份引进华南农业大学海洋学院工作，二级教授、博导。

l主要荣誉称号

享受国务院政府特殊津贴专家（2016）

广东省“扬帆计划”高层次人才（2013）

广东省高等学校“千百十工程”省级培养对象（2008）及先进个人（2012）

广东省高教系统“优秀共产党员”（2011）

华南农业大学“优秀共产党员”（2019）

首届“汕头市十大创新人物”（2010）

汕头市优秀拔尖人才（2009）

l学术兼职

在中国水产学会水产动物营养与饲料专业委员会、全国饲料工业标准化技术委员会水产饲料分技术委员会、广东水产学会水产动物营养与饲料专业委员会等10余个国家级或省级学术组织担任委员、理事或主任委员。

l代表性获奖成果、专著

       李远友等，“鱼类必需脂肪酸合成的分子基础及调控机制研究”成果获2023年度广东省自然科学奖二等奖；授奖单位：广东省人民政府。

       李远友等，“鱼类必需脂肪酸精准营养研究”成果获第十三届大北农科技奖二等奖（2024年）；授奖单位：北京大北农科技股份有限公司，大北农科技奖励委员会。

       李远友等，“青蟹病害综合防控及健康养殖技术的研究与应用”成果获2016年度广东省科学技术进步奖三等奖；授奖单位：广东省人民政府。

       李远友等，《鱼类脂肪酸精准营养的理论与应用实践》，科学出版社, 2023。

l代表性论文（*通讯作者）

  1.Yuanyou Li*, Monroig, O., Zhang, L., Wang, S., Zheng, X., Dick, J. R., You, C., Tocher, D. R.  2010. Vertebrate fatty acyl desaturase with ∆4 activity. PNAS, 107(9): 16840-16845.

  2.Dizhi Xie^#, Cuiying Chen^#, Yewei Dong^#, Cuihong You, Shuqi Wang*, Óscar Monroig*, Douglas R. Tocher, Yuanyou Li*. 2021. Regulation of long-chain polyunsaturated fatty acid biosynthesis in teleost fish. Progress in Lipid Research, 82: 101095.

  3.Junfeng Guan, Jianzhao Xu, Xin Gao, Zekui Huang, Chao Xu, Ermeng Yu, Dizhi Xie*, Yuanyou Li*. 2026. Blended Oil with an Optimized Fatty Acid Profile Improves Fishmeal Substitution Efficacy in Carnivorous Teleost Largemouth Bass Diet. Aquaculture Nutrition, 2026:8841385.

  4.Guanrong Zhang, Jianzhao Xu, Fang Chen, Junfeng Guan, Ningning Su, Xin Gao, Dizhi Xie*, Yuanyou Li*. 2025. Dietary fatty acid composition modulates growth in the marine teleost Trachinotus ovatus by regulating the hepatic triglyceride to (phosphatidylcholine + phosphati- dylethanolamine) ratio via the Ampk/Srebp signaling pathway. Aquaculture, 607: 742660.

  5.Ningning Su, Jun Zheng, Guanrong Zhang, Wenqiang An, Fang Chen, Chao Xu, Dizhi Xie, and Yuanyou Li*. 2025. Tissue-Specific Mechanism of Fat Distribution in Teleosts: Comparative Analysis Between Two Carnivorous Marine Species, Golden Pompano (Trachinotus ovatus) and Spotted Sea Bass (Lateolabrax maculatus). Aquaculture Nutrition, 1005455.

  6.Xin Gao, Mengmeng Li, Junfeng Guan, Zhiyi Cheng, Dizhi Xie and Yuanyou Li*. 2025. Transcriptomic Analysis Reveals Regulatory Responses of Fatty Acid Positional Distribution in Triacylglycerols and Lipid Composition to Dietary n-3 HUFA in the Muscle of Trachinotus ovatus. Animals, 15, 2427.

  7.Zhang, G.R., Ning, L.J., Jiang, K.S., Li, H.J., Ma, Y.C., Wu, K., Xu, C., Xie, D.Z., Chen, F., Wang, S.Q., Li, Y.Y*. 2023.. The importance of fatty acid precision nutrition: effects of dietary fatty acid composition on growth, hepatic metabolite and intestinal microbiota in marine teleost Trachinotus ovatus. Aquaculture Nutrition, 2023: 2556799.

  8.An, W.Q., Xu, J.Z., Chen, F., Ma, Y.C., Su, Z.L., Guan, J.F., Su, N.N., Zhang, G.R., Xu, C., Li, Y.Y*, Dizhi Xie*. 2023. Effects of dietary n-3 LC-PUFA levels on the growth, immunity, and lipid metabolism of freshwater carnivorous teleost largemouth bass (Micropterus salmoides) juveniles. Aquaculture Reports, 32: 101704.

  9.Liu, L.J., Chen, C.Y., Dong, Y.W., Cheng Y., You, C.H., Wang, S.Q., Ma, H.Y*., Li, Y.Y*. 2022. Insulin activates LC-PUFA biosynthesis of hepatocytes by regulating the PI3K/Akt/ mTOR/Srebp1 pathway in teleost Siganus canaliculatus. Comparative Biochemistry and Physiology B, 260: 110734.

  10.Lei, C.X., Fan, B., Tian, J.J., Li, M.M., Li, Y.Y*. 2022. PPARγ regulates fabp4 expression to increase DHA content in golden pompano (Trachinotus ovatus) hepatocytes. British Journal of Nutrition, 127(1): 3-11.

  11.Dong, Y.W, Liu, L.J, Li, M.M., Xie, D.Z, Zhao J.H., Wang, S.Q., You, C.H., Li, Y.Y* 2022. Insulin can up-regulate LC-PUFA biosynthesis with the involvement of Srebp-1c and stimulatory protein 1 (Sp1) in marine teleost Siganus canaliculatus. Gene, 840: 146755.

  12.Fan, B., Xie, D.Z., Li, Y.W., Wang, X.L., Qi, X., Li, S.S., Meng, Z.N., Chen, X.H., Peng, J.Y., Yang, Y.J., Li, Y.Y*., Wang, L*. 2021. A single intronic single nucleotide polymorphism in splicing site of steroidogenic enzyme hsd17b1 is associated with phenotypic sex in oyster pompano, Trachinotus anak. Proceedings of The Royal Society B, 288: 20212245.

  13.Cuiying Chen, Shuqi Wang, Yu Hu, Mei Zhang, Xianda He, Cuihong You, Xiaobo Wen, Óscar Monroig, Douglas R. Tocher, and Yuanyou Li*. 2020. miR-26a mediates LC-PUFA biosynthesis by targeting the Lxrα-Srebp1 pathway in the marine teleost Siganus canaliculatus. Journal of Biological Chemistry, 295: 13875-13886.

  14.Dizhi Xie, Meng Wang, Shuqi Wang, Cuihong You, Mengmeng li, Yongcai Ma, Lihua Sun, Yong Wang, Yuanyou Li*. 2020. Fat powder can be a feasible lipid source in aquafeed for the carnivorous marine teleost golden pompano, Trachinotus ovatus. Aquaculture International, 28: 1153-1168.

  15.Yongcai Ma, Mengmeng Li, Dizhi Xie, Shijun Chen, Yewei Dong, Meng Wang, Guanrong Zhang, Mei Zhang, Hanyi Chen, Rukai Ye, Yong Wang, Lihua Sun, Shuqi Wang, Lijun Ning, A.K.M. Munzurul Hasan, Yuanyou Li*. 2020. Fishmeal can be replaced with a high proportion of terrestrial protein in the diet of the carnivorous marine teleost (Trachinotus ovtus). Aquaculture, 519: 734910.

  16.Junjun Sun, Cuiying Chen, Cuihong You, Yang Liu, Hongyu Ma, Óscar Monroig, Douglas R. Tocher, Shuqi Wang*, Yuanyou Li*. 2020. The miR-15/16 Cluster Is Involved in the Regulation of Vertebrate LC-PUFA Biosynthesis by Targeting pparγ as Demonostrated in Rabbitfish Siganus canaliculatus. Marine Biotechnology, 22(4): 475-487.

  17.Mengmeng Li, Mei Zhang, Yongcai Ma, Rukai Ye, Meng Wang, Hanyi Chen, Dizhi Xie, Yewei Dong, Lijun Ning, Cuihong You, Shuqi Wang, Yuanyou Li*. 2020. Dietary supplementation with n-3 high unsaturated fatty acids decreases serum lipid levels and improves flesh quality in the marine teleost golden pompano Trachinotus ovatus. Aquaculture, 516: 734632.

  18.Shuqi Wang, Meng Wang, Hao Zhang, Xin Yan, Haoji Guo, Cuihong You, Douglas R. Tocher, Cuiying Chen, Yuanyou Li*. 2020. Long-chain polyunsaturated fatty acids biosynthesis in carnivorous marine teleost: insight into the profile of LC-PUFA biosynthesis in golden pompano Trachinotus ovatus. Aquaculture Research, 51(2): 623-635.

  19.Wenju Xu, Shuqi Wang, Cuihong You, Yueling Zhang, Óscar Monroig, Douglas R Tocher, Yuanyou Li*. 2020. The catadromous teleost Anguilla japonica has a complete enzymatic repertoire for the biosynthesis of docosahexaenoic acid from α-linolenic acid: Cloning and functional characterization of an Elovl2 elongase. Comparative Biochemistry and Physiology Part B, 240: 110373.

  20.Yang Li, Zhengyong Wen, Cuihong You, Zhiyong Xie, Douglas R. Tocher, Yueling Zhang, Shuqi Wang, Yuanyou Li*. 2020. Genome wide identification and functional characterization of two LC-PUFA biosynthesis elongase (elovl8) genes in rabbitfish (Siganus canaliculatus). Aquaculture, 522: 735127.

  21.Wen, Z.Y., Li, Y., Bian, C., Shi, Q^⁎., Li, Y.Y^⁎. 2020. Genome-wide identification of a novel elovl4 gene and its transcription in response to nutritional and osmotic regulations in rabbitfish (Siganus canaliculatus). Aquaculture, 529: 735666.

  22.Yuanyou Li*, Jianhong Zhao, Yewei Dong, Ziyan Yin, Yang Li, Yang Liu, Cuihong You, Óscar Monroig, Douglas R. Tocher and Shuqi Wang*. 2019. Sp1 is Involved in Vertebrate LC-PUFA Biosynthesis by Upregulating the Expression of Liver Desaturase and Elongase Genes. International Journal of Molecular Sciences, 20: 5066.

  23.Yuanyou Li*, Ziyan Yin, Yewei Dong, Shuqi Wang, Óscar Monroig, Douglas R. Tocher, Cuihong You*. 2019. Pparγ Is Involved in the Transcriptional Regulation of Liver LC-PUFA Biosynthesis by Targeting the Δ6Δ5 Fatty Acyl Desaturase Gene in the Marine Teleost Siganus canaliculatus. Marine Biotechnology, 21: 19–29.

  24.Mei Zhang, Cuiying Chen, Cuihong You, Baojia Chen, Shuqi Wang*, Yuanyou Li*. 2019. Effects of different dietary ratios of docosahexaenoic to eicosapentaenoic acid (DHA/EPA) on the growth, non-specifc immune indices, tissue fatty acid compositions and expression of genes related to LC-PUFA biosynthesis in juvenile golden pompano Trachinotus ovatus.Aquaculture, 505: 488–495.

  25.Yuanyou Li*, Xiaowei Zeng, Yewei Dong, Cuiying Chen, Cuihong You, Guoxia Tang, Junliang Chen and Shuqi Wang. 2018. Hnf4α is involved in LC-PUFA biosynthesis by up-regulating gene transcription of elongase in marine teleost Siganus canaliculatus. International Journal of Molecular Sciences, http://doi:10.3390/ijms19103193.

  26.Dizhi Xie, Zhixiang Fu, Shuqi Wang, Cuihong You, Óscar Monroig, Douglas R. Tocher, Yuanyou Li*. 2018. Characteristics of the fads2 gene promoter in marine teleost Epinephelus coioides and role of Sp1-binding site in determining promoter activity. Scientific Reports, 8: 5305.

  27.Cuiying Chen, Jiashun Chen, Shuqi Wang, Cuihong You, Yuanyou Li*. 2017. Effects of different dietary ratios of linolenic to linoleic acids or docosahexaenoic to eicosapentaenoic acids on the growth and immune indices in grouper, Epinephelus coioides. Aquaculture, 473: 153-160.

  28.You, C., Miao, S., Lin, S., Wang, S., Waiho, K., & Li, Y*. 2017. Expression of long-chain polyunsaturated fatty acids (LC-PUFA) biosynthesis genes and utilization of fatty acids during early development in rabbitfish Siganus canaliculatus. Aquaculture, 479: 774-779.

  29.Liu, Y., Zhang, Q. H., Dong, Y. W., You, C. H., Wang, S. Q., Li, Y. Q. & Li, Y. Y*. 2017. Establishment of a hepatocyte line for studying biosynthesis of long‐chain polyunsaturated fatty acids from a marine teleost, the white-spotted spinefoot Siganus canaliculatus. Journal of Fish Biology, 91(2):603-616.

  30.Qinghao Zhang, Dizhi Xie, Shuqi Wang, Cuihong You, Óscar Monroig, Douglas R. Tocher, Yuanyou Li*. 2014. miR-17 is involved in the regulation of LC-PUFA biosynthesis in vertebrates: effects on liver expression of a fatty acyl desaturase in the marine teleost Siganus canaliculatus. BBA- Molecular and Cell Biology of Lipids, 1841: 934-943.

  31.Qinghao Zhang, Shuqi Wang, Cuihong You, Yewei Dong, Óscar Monroig, Douglas R. Tocher, Yuanyou Li*. 2016. The miR-33 gene is identified in a marine teleost: a potential role in regulation of LC-PUFA biosynthesis in Siganus canaliculatus. Scientific Reports, 6: 32909.

  32.Yewei Dong, Shuqi Wang, Junliang Chen, Qinghao Zhang, Yang Liu, Cuihong You, Óscar Monroig, Douglas R. Tocher, Yuanyou Li*. 2016. Hepatocyte Nuclear Factor 4α (HNF4α) Is a Transcription Factor of Vertebrate Fatty Acyl Desaturase Gene as Identified in Marine Teleost Siganus canaliculatus. PLoS One, DOI: 10.1371/journal.pone.0160361.

  33.Shuqi Wang, Óscar Monroig, GuoxiaTang, Liang Zhang, Cuihong You, Douglas R. Tocher, Yuanyou Li*. 2014. Investigating long-chain polyunsaturated fatty acid biosynthesis in teleost fish: Functional characterization of fatty acyl desaturase (Fads2) and Elovl5 elongase in the catadromous species, Japanese eel Anguilla japonica. Aquaculture, 434: 57-65.

  34.Óscar Monroig, Shuqi Wang, Liang Zhang, Cuihong You, Douglas R. Tocher, Yuanyou Li*. 2012. Elongation of long-chain fatty acids in rabbitfish Siganus canaliculatus: Cloning, functional characterization and tissue distribution of Elovl5- and Elovl4-like elongases. Aquaculture, 350-353:63-70.

  35.Shude Xu, Shuqi Wang, Liang Zhang, Cuihong You, Yuanyou Li*. 2012. Effects of replacement of dietary fish oil with soybean oil on growth performance and tissue fatty acid composition in marine herbivorous teleost Siganus canaliculatus. Aquaculture Research, 43 (9):1276-1286.

  36.Yuanyou Li*, Changbo Hu, Yijun Zheng, Xiaoan Xia, Wenju Xu, Weizhou Chen, Zewei Sun, Junhui Huang. 2008. The effects of dietary fatty acids on liver fatty acid composition and Δ6 -desaturase expression differ with ambient salinities in Siganus canaliculatus. Comparative Biochemistry and Physiology, Parts B, 151: 183-190.

  37.Yuanyou Li*, Weizhou Chen, Zewei Sun, Jiehui Chen, Kegang Wu. 2005. Effects of n-3 HUFA content in broodstock diet on spawning performance and fatty acid composition of eggs and larvae in Plectorhynchus cinctus. Aquaculture, 245: 263-272.

  38.YY Li, K Inoue and Y Takei. 2003. Interrenal steroid 21-hydroxylase in eels: primary structure, progesterone-specific activity and enhanced expression by ACTH. Journal of Molecular Endocrinology, 31: 327-340.

  39.YuanYou Li and Yoshio Takei. 2003. Ambient salinity-dependent effects of homologous natriuretic peptides (ANP, VNP and CNP) on plasma cortisol level in the eel. General and Comparative Endocrinology, 130 (3): 317-325.  

  40.YuanYou Li, Koji. Inoue and Yoshio Takei. 2003. Steroidogenic acute regulatory protein in eels: cDNA cloning and effects of ACTH and seawater transfer on its mRNA expression. Zoological Science, 20: 211-219.

  41.李远友^⁎, 李孟孟, 汪萌, 张媚, 麻永财, 张关荣, 陈汉毅, 宁丽军, 谢帝芝, 王树启, 游翠红. 2019. 卵形鲳鲹(Trachinotus ovatus)营养需求与饲料研究进展. 渔业科学进展, 40 (1): 167-177.

  42.麻永财, 张关荣, 李孟孟, 陈汉毅, 宁丽军, 谢帝芝, 李远友*. 2019. 军曹鱼营养需求与饲料研究进展. 水生生物学报, 43(3): 680-692.

  43.叶儒锴, 郑钧, 李孟孟, 陈汉毅, 麻永财, 谢帝芝, 宁丽军, 孙丽华, 王勇, 李远友*. 2019. 液态和粉末脂肪对吉富罗非鱼生长、健康及肌肉品质的影响. 水产学报, 43(10): 2197-2208.

  44.谢帝芝, 徐树德, 陈芳, 王树启, 游翠红, 李远友*. 2015. 黄斑蓝子鱼LC-PUFA合成代谢与渗透压调节的关系研究. 中国水产科学, 22(5): 950-959.

  45.陈伟洲, 李远友*, 孙泽伟, 黄俊辉, 杜永兵, 谭燕. 2006. 饲料中n-3 HUFA含量对花尾胡椒鲷亲鱼组织的脂质含量和脂肪酸构成的影响. 华南农业大学学报, 27(1): 96-100.

  46.李远友, 孙泽伟, 杨云霞, 解绶启, 崔奕波. 2004. 尼罗罗非鱼在淡水和海水中的生长及对蛋白质需求的比较. 水产科学, 23(10): 1-4.