李远友

  • 李远友

    姓名:李远友

    职务:水生动物营养与饲料科学系主任

    职称:教授

    联系方式:yyli16@scau.edu.cn

个人简介:

男,中山大学博士,日本东京大学博士后;现为华南农业大学二级教授、博士生和硕士生导师,海洋学院水生动物营养与饲料科学系主任、营养与资源党支部书记;国家海水鱼产业技术体系岗位科学家(营养需求与饲料领域)。曾任汕头大学理学院副院长、海洋生物研究所所长兼广东省海洋生物技术重点实验室主任等职。

主要研究方向为水产动物营养与饲料学。作为项目负责人,已主持承担包括国家自然科学基金重点国际合作研究项目在内的省部级以上科研课题20多项,其中国家基金8项。在包括国际顶级科技期刊PNAS(美国科学院院刊)在内的国内外学术期刊上发表论文140多篇,其中SCI论文80余篇;获得包括省科技进步奖在内的学术和科研奖励10多次;向世界基因库登记新基因序列31个,参编著作3部,获授权国家发明专利5件,制订农业地方标准3项。在鱼类脂肪营养,特别是高不饱和脂肪酸(HUFA)合成代谢调控机制、脂肪酸精准营养与配合饲料的鱼油替代技术等方面,其研究工作取得多项重要创新性突破,相关成果居国际前沿水平。

  


工作经历:

1989.6-1995.8:湖南农业大学动物科技学院水产系助教、讲师,系党支部书记;

1998.7-2016.12:汕头大学海洋生物研究所/广东省海洋生物技术重点实验室工作,硕导、博导;2004年晋升教授,2011年获聘二级教授岗。2007.12-2016.12,担任海洋生物研究所所长兼广东省海洋生物技术重点实验室主任、海洋生物学科负责人;

2007.12-2009.4,兼任生物系主任;2010.11-2014.3,兼任理学院副院长。

2000.11-2002.11:东京大学海洋研究所博士后,特聘研究员。

2014.7-2014.8:东京大学大气与海洋研究所客座教授。

2016.12-至今:华南农业大学二级教授,博士生导师,海洋学院水生动物营养与饲料科学系主任、营养与资源党支部书记。


教育经历:

1982.9-1989.6:湖南师范大学本科生及硕士生,获理学学士和硕士学位,硕士导师刘筠院士
1995.9-1998.6:中山大学生命科学学院博士生,获博士学位,导师林浩然院士


获奖、荣誉称号:

“青蟹病害综合防控及健康养殖技术的研究与应用”成果获得2016年度广东省科学技术进步奖三等奖(第一完成人)

“华贵栉孔扇贝‘南澳金贝’的培育技术研究及应用”成果于2018年获得海洋科学技术奖二等奖(第7完成人),颁奖单位:国家海洋局,中国海洋学会,中国太平洋学会,中国海洋湖沼学会

华南农业大学“优秀共产党员”(2019)

享受国务院政府特殊津贴专家(2016)

广东省“扬帆计划”高层次人才(2013)

广东省高等学校“千百十工程”省级培养对象先进个人(2012)

广东省高教系统“优秀共产党员”(2011)

广东省高等学校“千百十工程”省级培养对象(2008)

首届“汕头市十大创新人物”(2010)

汕头市优秀拔尖人才(2009)

汕头大学学生课外学术科技活动“优秀指导教师奖”(2012)


学术兼职:

教育部学位与研究生教育评估专家

国家基金委第十四届生命科学部水产学专家评审组专家

广东省第五届、第六届学位委员会学科评议组成员

广东省海洋科学本科教学指导委员会委员

湖南省水生动物营养与品质调控重点实验室学术委员会委员

福建省海洋渔业资源与生态环境重点实验室学术委员会委员

海南省热带海洋渔业资源保护与利用重点实验室学术委员会委员

中国海洋湖沼学会海洋生物技术分会理事

中国水产学会水产生物技术专业委员会委员

中国水产学会第十届理事会水产动物营养与饲料专业委员会

中国水产学会第十届理事会海水养殖分会委员

中国农村专业技术协会第五届理事会海水养殖专业委员会委员

广东省动物学会第十三届理事会副秘书长

广东省海洋学会及海洋湖沼学会理事

广东省水产学会常务理事


研究领域:

水产动物营养与饲料学;鱼类生理及分子生物学;水产养殖生态学


科研项目:

主持承担省部级以上科研课题20多项,其中国家基金8项。代表性项目如下:

1. 国家海水鱼产业技术体系岗位科学家项目:军曹鱼卵形鲳鲹营养需求与饲料。项目编号:CARS-47-G13;实施期:2017.1-2020.12.

2. 国家重点研发计划“蓝色粮仓科技创新”重点专项“水产动物精准营养及其代谢调控机制”(PI)。项目编号:2018YFD0900400;实施期:2018.12-2022.12.

3. 国家自然科学基金面上项目:广盐性鱼类在不同盐度下的HUFA合成能力的影响机制研究;项目编号:31873040 ;实施期:2019.1-2022.12.

4. 广东省促进经济高质量发展专项资金海洋经济发展项目:卵形鲳鲹高效低成本环保配合饲料的研发及其产业化应用。项目编号:GDOE【2019】A30号; 实施期:2019.1-2020.12。

5. 国家自然科学基金重点国际合作研究项目:鱼类HUFA合成能力多样性的分子解释与调控机理研究。项目编号:31110103913;实施期:2012.1-2017.12。

6. 国家基金面上项目:饲料ω3多不饱和脂肪酸影响花尾胡椒鲷生殖性能的机制。项目编号:30070599;实施期:2001.1-2003.12。

7. 国家基金面上项目:蓝子鱼高度不饱和脂肪酸合成的分子调控机制研究。项目编号:30972266;实施期:2010.1-2012.12。

8. 国家基金面上项目:植食性海水鱼类消化利用大型海藻的机制与海藻资源的饲料化利用。项目编号:41276179;实施期:2013.1-2016.12。

9. 国家基金面上项目:内分泌干扰物影响鱼类类固醇激素生物合成的机制及其与环境盐度的关系。项目编号:30570325;实施期:2006.1-2008.12。

10. 国家基金中英国际合作交流项目:蓝子鱼脂肪酸去饱和酶基因调控子的分析研究。项目编号:31011130156;实施期:2010.4 -2012.3。

11. 科技部国家科技支撑计划项目“南海附近海岸带生态修复及大型海藻利用技术与示范”子课题。项目编号:2012BAC07B05;实施期:2012.1-2015.12。

12. 广东省自然科学基金研究团队项目:海水鱼利用大型海藻的机制及其应用研究 (第2核心成员,共5名)。项目编号:S2011030005257;实施期:2011.10-2016.12。

13. 教育部高等学校博士学科点专项科研基金:蓝子鱼脂肪酸去饱和酶功能特异性的分子基础研究。项目编号:20104402110002;实施期:2011.1-2013.12。

14. 广东省科技计划重点项目:低值、残次海藻的饲料化和高值化利用技术研究及应用示范。项目编号:2010B030600006;实施期:2010.10-2012.9。

15. 广东省教育部产学研结合项目:高效、低成本海水鱼配合饲料的研发及推广应用。项目编号:2011B090400039;实施期:2011.10-2013.9。

16. 广东省科技计划农业攻关项目:盐度对鱼体必需脂肪酸需求的影响与广盐性鱼类的饲料配方研制。项目编号:2005B20301013;实施期:2006.1-2008.12。

17. 广东省“扬帆计划”培养高层次人才项目:鱼类HUFA合成代谢调控机制及其应用研究。项目编号:40010209;实施期:2013.10-2016.9。

18. 广东高校产学研结合示范基地科技成果转化重大项目:锯缘青蟹病害防控及健康养殖技术应用示范与推广。项目编号:cgzhzd0812;实施期:2009.1-2011.12。 


参编著作:

1. 李远友, 徐树德. 蓝子鱼对海藻的有效利用. 近海环境生态修复与大型海藻资源利用. p. 234-263(约4.5万字). 杨宇峰等著, 科学出版社. 2016.

2. 李远友. 鱼类的HUFA合成能力及进化. 10000个科学难题农业科学卷,p.789-792. “10000个科学难题”农业科学编委会. 科学出版社, 2011. 

3. Yuanou Li, Chunxiang Ai and Lijie Liu. 2019. Mud Crab, Scylla paramamosain. China's Leading maricultured crab. In: Jianfang Gui, Qisheng Tang, Zhangjie Li, Jiashou Liu and Sena S. De Sliva (Eds.), Aquaculture in China: Success Stories and Modern Trends. John Wiley & Sons Ltd. pp. 226-233.

4. Yuanyou Li, Qinghao Zhang & Yang Liu. 2019. Rabbitfish – an emerging herbivorous marine aquaculture species. In: Jianfang Gui, Qisheng Tang, Zhangjie Li, Jiashou Liu and Sena S. De Sliva (Eds.), Aquaculture in China: Success Stories and Modern Trends. John Wiley & Sons Ltd. pp. 329-334.


发表论文:

在包括国际顶级综合性科技期刊PNAS(美国科学院院刊)在内的国内外重要学术期刊上发表论文140多篇,其中SCI论文80余篇。代表性论文如下:

1.Yuanyou Li*, Monroig, O., Zhang, L., Wang, S., Zheng, X., Dick, J. R., You, C., Tocher, D. R.  2010. Vertebrate fatty acyl desaturase with 4 activity. PNAS, 107(9): 16840-16845. 

2.Meng wang, Shuqi Wang*, Hao Zhang, Xin Yan, Haoji Guo, Cuihong You, Cuiying Chen, Yuanyou Li*. 2020. Long-chain polyunsaturated fatty acids biosynthesis in carnivorous marine teleost: insight into the profile of LC-PUFA biosynthesis in golden pompano Trachinotus ovatus. Aquaculture Research, 28: 1153-1168.

3.  Yongcai Ma, Mengmeng Li, Dizhi Xie, Shijun Chen, Yewei Dong, Meng Wang, Guanrong Zhang, Mei Zhang, Hanyi Chen, Rukai Ye, Yong Wang, Lihua Sun, Shuqi Wang, Lijun Ning, A.K.M. Munzurul Hasan, Yuanyou Li*. 2020. Fishmeal can be replaced with a high proportion of terrestrial protein in the diet of the carnivorous marine teleost (Trachinotus ovtus). Aquaculture, 519: 734910.

4.  Junjun Sun, Cuiying Chen, Cuihong You, Yang Liu, Hongyu Ma, Óscar Monroig, Douglas R. Tocher, Shuqi Wang*, Yuanyou Li*. 2020. The miR-15/16 Cluster Is Involved in the Regulation of Vertebrate LC-PUFA Biosynthesis by Targeting pparγ as Demonostrated in Rabbitfish Siganus canaliculatus. Marine Biotechnology, https://doi.org/10.1007/s10126-020-09969-0

5.  Dizhi Xie, Meng Wang, Shuqi Wang, Cuihong You, Mengmeng Li, Yongcai Ma, Lihua Sun, Yong Wang, Yuanyou Li*. 2020. Fat powder can be a feasible lipid source in aquafeed for the carnivorous marine teleost golden pompano, Trachinotus ovatus. Aquaculture International, 28: 1153-1168.

6.  Caixia Lei, Mengmeng Li, Jingjing Tian, Jikai Wen*, Yuanyou Li*. 2020. Transcriptome analysis of golden pompano (Trachinotus ovatus) liver indicates a potential regulatory target involved in HUFA uptake and deposition. Comparative Biochemistry and Physiology-Part D: Genomics and Proteomics, 33: 100633.

7.  Mengmeng Li, Mei Zhang, Yongcai Ma, Rukai Ye, Meng Wang, Hanyi Chen, Dizhi Xie, Yewei Dong, Lijun Ning, Cuihong You, Shuqi Wang, Yuanyou Li*. 2020. Dietary supplementation with n-3 high unsaturated fatty acids decreases serum lipid levels and improves flesh quality in the marine teleost golden pompano Trachinotus ovatus. Aquaculture, 516: 734632.

8.  Zhengyong Wen, Chao Bian, Xinxin You, Xinhui Zhang, Jia Li, Qiuyao Zhan, Yuxiang Peng, Yuanyou Li*, Qiong Shi*. 2020. Characterization of two kcnk3 genes in Nile tilapia (Oreochromis niloticus): Molecular cloning, tissue distribution, and transcriptional changes in various salinity of seawater. Genomics, https://doi.org/10.1016/j.ygeno.2019.12.017

9.  Dizhi Xie, Jialing Ye, Meisong Lu, Shuqi Wang, Cuihong You & Yuanyou Li*. 2020. Comparsion of Activities of Fatty Acyl Desaturases and Elongases Among Six Teleosts With Different Feeding and Ecological Habits. Frontiers in Marine Science, 7:117.

10. Yewei Dong, Shuqi Wang, Cuihong You, Dizhi Xie,Qingyan Jiang, Yuanyou Li*. 2020. Hepatocyte nuclear factor 4α (Hnf4α) is involved in transcriptional regulation of Δ6/Δ5 fatty acyl desaturase (Fad) gene expression in marine teleost Siganus canaliculatus. Comparative Biochemistry and Physiology, Part B, 239: 110353.

11. Wenju Xu, Shuqi Wang, Cuihong You, Yueling Zhang, Óscar Monroig, Douglas R Tocher, Yuanyou Li*. 2020. The catadromous teleost Anguilla japonica has a complete enzymatic repertoire for the biosynthesis of docosahexaenoic acid from α-linolenic acid: Cloning and functional characterization of an Elovl2 elongase. Comparative Biochemistry and Physiology Part B, 240: 110373.

12. Yang Li, Zhengyong Wen, Cuihong You, Zhiyong Xie, Douglas R. Tocher, Yueling Zhang, Shuqi Wang, Yuanyou Li*. 2020. Genome wide identification and functional characterization of two LC-PUFA biosynthesis elongase (elovl8) genes in rabbitfish (Siganus canaliculatus). Aquaculture, 522: 735127.

13.Yuanyou Li*, Jianhong Zhao, Yewei Dong, Ziyan Yin, Yang Li, Yang Liu, Cuihong You , Óscar Monroig, Douglas R. Tocher and Shuqi Wang. 2019. Sp1 is Involved in Vertebrate LC-PUFA Biosynthesis by Upregulating the Expression of Liver Desaturase and Elongase Genes. International Journal of Molecular Sciences, 20: 5066.

14. Cuiying Chen, Shuqi Wang, Mei Zhang, Baojia Chen, Cuihong You, Dizhi Xie, Yang Liu, Óscar Monroig, Douglas R. Tocher, Khor Waiho, Yuanyou Li*. 2019. miR-24 is involved in vertebrate LC-PUFA biosynthesis as demonstrated in marine teleost Siganus canaliculatus. BBA-Molecular and Cell Biology of Lipids, 1864: 619628.

15.Yuanyou Li*, Ziyan Yin, Yewei Dong, Shuqi Wang, Óscar Monroig, Douglas R. Tocher, Cuihong You*. 2019. Pparγ Is Involved in the Transcriptional Regulation of Liver LC-PUFA Biosynthesis by Targeting the Δ6Δ5 Fatty Acyl Desaturase Gene in the Marine Teleost Siganus canaliculatus. Marine Biotechnology, 21: 1929.

16. Cuihong You, Fangbin Lu, Shuqi Wang, Cuiying Chen, Yuanyou Li*. 2019. Comparison of the growth performance and long-chain PUFA biosynthetic ability of the genetically improved farmed tilapia (Oreochromis niloticus) reared in different salinities. British Journal of Nutrition, 121: 374383.

17. Mei Zhang, Cuiying Chen, Cuihong You, Baojia Chen, Shuqi Wang*, Yuanyou Li*. 2019. Eects of dierent dietary ratios of docosahexaenoic to eicosapentaenoic acid (DHA/EPA) on the growth, non-specifc immune indices, tissue fatty acid compositions and expression of genes related to LC-PUFA biosynthesis in juvenile golden pompano Trachinotus ovatus.Aquaculture, 505: 488495.

18. Cuihong You, Baojia Chen, Meng Wang, Shuqi Wang, Mei Zhang, Zhijie Sun, Aweya Jude Juventus, Hongyu Ma, Yuanyou Li*. 2019. Effects of dietary lipid sources on the intestinal microbiome and health of golden pompano (Trachinotus ovatus). Fish and Shellfish Immunology, 89: 187197.

19. Dizhi Xie, Xi Li, Cuihong You, Shuqi Wang, Yuanyou Li *. 2019. Supplementation of macroalgae together with non-starch polysaccharide degrading enzymes in diets enhanced growth performance, innate immune indexes and disease resistance against Vibrio parahaemolyticus in rabbitfish Siganus canaliculatus. Journal of Applied Phycology, 31: 2073-2083. 

20. ZhengYong Wen, Jun Wang, Chao Bian, Xinghui Zhang, Xinying Zhou, Yuxiang Peng, Qiuyao Zhan, Qiong Shi*, Yuan-You Li*. 2019. Molecular cloning of two kcnk3 genes from the Northern snakehead (Channa argus) for quantification of their transcriptions in response to fasting and refeeding. General and Comparative Endocrinology,  281: 4957.

21. Jun Jun Sun, Li Guo Zheng, Cui Ying Chen, Jin Ying Zhang, Cui Hong You, Qing Hao Zhang, Hong Yu Ma, Óscar Monroig, Douglas R. Tocher, Shu Qi Wang*, Yuan You Li*. 2019. MicroRNAs Involved in the Regulation of LC-PUFA Biosynthesis in Teleosts: miR-33 Enhances LC-PUFA Biosynthesis in Siganus canaliculatus by Targeting insig1 which in Turn Upregulates srebp1. Marine Biotechnology, 21(4): 475-487.

22. Qing Wang, Huirong Yang, Min Yang, Yepin Yu, Muting Yan, Lei Zhou, Xiaochun Liu, Shiqiang Xiao, Yan Yang, Yuxin Wang, Leyun Zheng, Huihong Zhao*, Yuanyou Li*. 2019. Toxic effects of bisphenol A on goldfish gonad development and the possible pathway of BPA disturbance in female and male fish reproduction. Chemosphere, 221: 235-245.

23. Guanrong Zhang, Shuqi Wang, Cuiying Chen, Yongcai Ma, Dizhi Xie, Yong Wang, Lihua Sun, Cuihong You, Yuanyou Li*. 2019. Effects of dietary vitamin C on growth, flesh quality and antioxidant capacity of juvenile golden pompano Trachinotus ovatus. Aquaculture Research, 00:1-11.

24. Cuiying Chen, Jinying Zhang, Mei Zhang, Cuihong You, Yang Liu, Shuqi Wang, Yuanyou Li*. 2018. miR-146a is involved in the regulation of vertebrate LC-PUFA biosynthesis by targeting elovl5 as demonstrated in rabbitfish Siganus canaliculatus. Gene, 676: 306314. 

25.Yuanyou Li*, Xiaowei Zeng, Yewei Dong, Cuiying Chen, Cuihong You, Guoxia Tang, Junliang Chen and Shuqi Wang. 2018. Hnf4α is involved in LC-PUFA biosynthesis by up-regulating gene transcription of elongase in marine teleost Siganus canaliculatus. International Journal of Molecular Sciences, http://doi:10.3390/ijms19103193.

26. Yewei Dong, Jianhong Zhao, Junliang Chen, Shuqi Wang, Yang Liu, Qinghao Zhang, Cuihong You, Óscar Monroig, Douglas R. Tocher, Yuanyou Li*. 2018. Cloning and characterization of 6/5 fatty acyl desaturase (Fad) gene promoter in the marine teleost Siganus canaliculatus. Gene, 647:174-180.  

27. Shuqi Wang, Junliang Chen, Danli Jiang, Qinghao Zhang, Yewei Dong, Cuihong You, Douglas R. Tocher, Óscar Monroig, Yuanyou Li*. 2018. Hnf4α is involved in the regulation of vertebrate LC-PUFA biosynthesis: insights into the regulatory role of Hnf4α on expression of liver fatty acyl desaturases in the marine teleost Siganus canaliculatus. Fish Physiol Biochem, 44: 805815. 

28. Dizhi Xie, Zhixiang Fu, Shuqi Wang, Cuihong You, Óscar Monroig, Douglas R. Tocher, Yuanyou Li*. 2018. Characteristics of the fads2 gene promoter in marine teleost Epinephelus coioides and role of Sp1-binding site in determining promoter activity. Scientific Reports, 8:5305.

29.    Dizhi Xie, Xuebing Liu, Shuqi Wang, Cuihong You, Yuanyou Li*. 2018. Effects of dietary LNA/LA ratios on growth performance, fatty acid composition and expression levels of elovl5, Δ4 fad andΔ6/Δ5 fad in the marine teleost Siganus canaliculatus. Aquaculture. 484: 309316.

30. XIE Dizhi, XU Shude, WU Qingyang, CHEN Fang, WANG Shuqi, YOU Cuihong, LI Yuanyou*. 2018. Changes of visceral properties and digestive enzymes in the herbivorous marine teleost Siganus canaliculatus fed on different diets. Acta Oceanol. Sin., 37 (2): 8593. 

31. Shuqi Wang, Xuebing Liu, Shude Xu, Qingyang Wu, Cuihong You, Douglas R. Tocher, Yuanyou Li*. 2018. Total Replacement of Dietary Fish Oil with a Blend of Vegetable Oils in the Marine Herbivorous Teleost Siganus canaliculatus. Journal of the World Aquaculture Society, 49 (4): 692-702.

32. Cuiying Chen, Jiashun Chen, Shuqi Wang, Cuihong You, Yuanyou Li*. 2017. Effects of different dietary ratios of linolenic to linoleic acids or docosahexaenoic to eicosapentaenoic acids on the growth and immune indices in grouper, Epinephelus coioides. Aquaculture, 473: 153-160.

33. Cuihong You, Danli Jiang, Qinghao Zhang, Dizhi Xie, Shuqi Wang, Yewei Dong, Yuanyou Li*. 2017. Cloning and expression characterization of peroxisome proliferator-activated receptors (PPARs) with their agonists, dietary lipids, and ambient salinity in rabbitfish Siganus canaliculatus. Comparative Biochemistry and Physiology, Part B, 206: 5464. 

34. Zhang, Q., Wong, M. K., Li, Y., Li, Y*., & Takei, Y. 2017. Changes in Plasma and Tissue Long-Chain Polyunsaturated Fatty Acid (LC-PUFA) Content in the Eel Anguilla japonica After External and Internal Osmotic Stress. Zoological science, 34(5), 429-437. 

35. You, C., Miao, S., Lin, S., Wang, S., Waiho, K., & Li, Y*. 2017. Expression of long-chain polyunsaturated fatty acids (LC-PUFA) biosynthesis genes and utilization of fatty acids during early development in rabbitfish Siganus canaliculatus. Aquaculture, 479: 774-779.

36. Liu, Y., Zhang, Q. H., Dong, Y. W., You, C. H., Wang, S. Q., Li, Y. Q.,& Li, Y. Y*. 2017. Establishment of a hepatocyte line for studying biosynthesis of longchain polyunsaturated fatty acids from a marine teleost, the white-spotted spinefoot Siganus canaliculatus. Journal of fish biology, 91(2):603-616.

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