杨敏

杨敏：女，副教授，硕士研究生导师，主要研究方向为水产动物病害防控与抗病育种相关研究工作。在水产病害防控方面，主要研究内容包括水产动物流行病学调查，水产病原快速检测体系研发，水产病原入侵和感染机制，病原毒力因子分析，宿主免疫抵御机制，病原与宿主互作机制等；在抗病育种方面，主要研究内容包括病原感染模型构建，抗病性状筛选，抗病分子标记开发，抗病功能机制分析，抗病表型评估，抗病种质创新，抗病品系构建等。先后主持或参与国家级、省级等各级项目20余项，发表SCI论文40余篇，申请国家专利10余项。

工作经历：

2014.8-2016.6 中科院南海海洋研究所，博士后

2016.7-今 华南农业大学海洋学院，副教授、硕导

科研项目：

1. 国家重点研发计划   速生优质石斑鱼新品种培育 2022年12月-2026年12月.

2. 国家重点研发计划项目青年科学家项目 养殖石斑鱼生物风险控制及特定病原脱毒技术   2023年12月至2027年12月   

3. 国家自然科学基金项目 石斑鱼PPARα和PPARβ与SGIV抗感/易感性状关联的机制分析  2024年01-2027年12月                                                                                                 

4. 广东省农业厅种业振兴专项  大口黒鲈优良品种选育   2023年2月-2025年12月.                                           

5.  广东省科技专项资金（“大专项+任务清单”）石斑鱼优良抗病品系选育技术研发及产业化示范  2023年1月-2025年6月

6. 广州市农业农村局农业科研项目  加州鲈抗虹彩病毒优良品种选育与推广示范  2023年8月-2024年12月

7.  广州市科技特派员项目 常见淡水鱼类病害防控与健康养殖新技术示范推广 2023年3月--2025年3月

8.  广州市科技局基础与应用基础研究专题 石斑鱼MHCIa不同单倍型在虹彩病毒感染中的功能分析 2023年4月-2025年4月

9.  国家自然科学基金项目 石斑鱼抗虹彩病毒性状QTL定位与候选基因挖掘    2018.01-2020.12

10. 横向课题 养殖场对虾常见病原检测体系构建; 水产种质资源材料制备；广东省水产种质普查；养殖场常见鱼类病原检测评估等

发表论文：

1. Yang M, Wang Q, Wang S, Wang Y, Zeng Q, Qin Q. Transcriptomics analysis reveals candidate genes and pathways for susceptibility or resistance to Singapore grouper iridovirus in orange-spotted grouper (Epinephelus coioides). Dev Comp Immunol. 2019 Jan;90:70-79.

2. Yang M, Chen J, Li X, Huang J, Wang Q, Wang S, Wei S, Qin Q. The transcription factor NFYC positively regulates expression of MHCIa in the red-spotted grouper (Epinephelus akaara). Dev Comp Immunol. 2021 Sep 29;127:104272. doi: 10.1016/j.dci.2021.104272. Epub ahead of print. PMID: 34600022.

3. Yang M, Wang Q, Chen J, Wang Y, Zhang Y, Qin Q. Identification of candidate SNPs and genes associated with anti-RGNNV using GWAS in the red-spotted grouper, Epinephelus akaara. Fish Shellfish Immunol. 2021 May;112:31-37. doi: 10.1016/j.fsi.2021.02.010. Epub 2021 Feb 18. PMID: 33609701.

4. Yang M ,  Wei J ,  Li P , et al. MHC class IIα polymorphisms and their association with resistance/susceptibility to Singapore grouper iridovirus (SGIV) in orange-spotted grouper, Epinephelus coioides[J]. Aquaculture, 2016, 462:10-16.

5. Yang, M. ,  Wei, J. ,  Li, P. ,  Wei, S. ,  Huang, Y. , &  Qin, Q. . (2016). Mhc polymorphism and disease resistance to singapore grouper iridovirus (sgiv) in the orange-spotted grouper, epinephelus coioides. Science Bulletin, 61(9), 693-699.

6. Yang M, Chen J, Li X, Huang J, Wang Q, Wang S, Wei S, Qin Q. The transcription factor NFYC positively regulates expression of MHCIa in the red-spotted grouper (Epinephelus akaara). Dev Comp Immunol. 2022 Feb;127:104272.

7. Yang Z, Luo W, Huang Z, Guo M, He X, Fan Z, Wang Q, Qin Q, Yang M*, Lee X*. Genome-Wide Analysis of Differentially Expressed mRNAs and lncRNAs in Koi Carp Infected with Koi Herpesvirus. Viruses. 2022 Nov 18;14(11):2555.

8. Wang Q, Liu Y, Han C, Yang M, Huang F, Duan X, Wang S, Yu Y, Liu J, Yang H, Lu D, Zhao H, Zhang Y, Qin Q. Efficient RNA Virus Targeting via CRISPR/CasRx in Fish. J Virol. 2021 Sep 9;95(19):e0046121. doi: 10.1128/JVI.00461-21. Epub 2021 Sep 9. PMID: 34287045; PMCID: PMC8428388.

9. Li X, Huang J, Liu C, Chen J, Wang S, Wei S, Yang M, Qin Q. Grouper ATF1 plays an antiviral role in response to iridovirus and nodavirus infection. Fish Shellfish Immunol. 2022 Nov;130:380-390. doi: 10.1016/j.fsi.2022.09.043. Epub 2022 Sep 21. PMID: 36150412.

10. Chen J, Li X, Huang J, Wang Q, Wang S, Wei S, Qin Q, Yang M. The transcription factor RFX5 positively regulates expression of MHCIa in the red-spotted grouper (Epinephelus akaara). Fish Shellfish Immunol. 2022 Feb;121:370-379. doi: 10.1016/j.fsi.2022.01.023. Epub 2022 Jan 17. PMID: 35051562.

11. Yang Z, Luo W, Huang Z, Guo M, He X, Fan Z, Wang Q, Qin Q, Yang M, Lee X. Genome-Wide Analysis of Differentially Expressed mRNAs and lncRNAs in Koi Carp Infected with Koi Herpesvirus. Viruses. 2022 Nov 18;14(11):2555. doi: 10.3390/v14112555. PMID: 36423164; PMCID: PMC9694643.

12.Wang Q, Peng C, Yang M, Huang F, Duan X, Wang S, Cheng H, Yang H, Zhao H, Qin Q. Single-cell RNA-seq landscape midbrain cell responses to red spotted grouper nervous necrosis virus infection. PLoS Pathog. 2021 Jun 29;17(6):e1009665. doi: 10.1371/journal.ppat.1009665. PMID: 34185811; PMCID: PMC8241073.

13.Luo W, Qi H, Huang Z, Guo M, Peng D, Yang Z, Fan Z, Wang Q, Qin Q, Yang M, Lee X. Autophagy induced by Cyprinid herpesvirus 3 (CyHV-3) facilitated intracellular viral replication and extracellular viral yields in common carp brain cells. Fish Shellfish Immunol. 2023 Oct;141:109049. doi: 10.1016/j.fsi.2023.109049. Epub 2023 Sep 9. PMID: 37678483.

14. Wang Q, Yang M, Li C, Wang S, Wang Y, Lin F, Zheng L, Yu Y, Qin Q. Functional analysis of the CXCR1a gene response to SGIV viral infection in grouper. Fish Shellfish Immunol. 2019 May;88:217-224. doi: 10.1016/j.fsi.2019.02.046. Epub 2019 Feb 23. PMID: 30807858.

15. Yang M, Li P, Qin Q, Zhu K. The complete mitochondrial genome of false trevally Lactarius Lactarius (Bloch and Schneider, 1801). Mitochondrial DNA B Resour. 2019 Dec 11;5(1):87-89. doi: 10.1080/23802359.2019.1698335. PMID: 33366435; PMCID: PMC7720941.

16.Chen J, Wang L, Huang J, Li X, Guan L, Wang Q, Yang M, Qin Q. Functional analysis of a novel MHC-Iα genotype in orange-spotted grouper: Effects on Singapore grouper iridovirus (SGIV) replication and apoptosis. Fish Shellfish Immunol. 2022 Feb;121:487-497. doi: 10.1016/j.fsi.2022.01.030. Epub 2022 Jan 22. PMID: 35077868.

17.Li P, Zhou L, Yu Y, Yang M, Ni S, Wei S, Qin Q. Characterization of DNA aptamers generated against the soft-shelled turtle iridovirus with antiviral effects. BMC Vet Res. 2015 Sep 30;11:245. doi: 10.1186/s12917-015-0559-6. PMID: 26419355; PMCID: PMC4588899.

18.Yang M, Wang Q, Chen J, Wang Y, Zhang Y, Qin Q. Identification of candidate SNPs and genes associated with anti-RGNNV using GWAS in the red-spotted grouper, Epinephelus akaara. Fish Shellfish Immunol. 2021 May;112:31-37. doi: 10.1016/j.fsi.2021.02.010. Epub 2021 Feb 18. PMID: 33609701.

19. Wang Y, Yu Y, Wang Q, Wei S, Wang S, Qin Q, Yang M. PPAR-δ of orange-spotted grouper exerts antiviral activity against fish virus and regulates interferon signaling and inflammatory factors. Fish Shellfish Immunol. 2019 Nov;94:38-49. doi: 10.1016/j.fsi.2019.08.068. Epub 2019 Aug 27. PMID: 31470135.

20. Li P, Wei S, Zhou L, Yang M, Yu Y, Wei J, Jiang G, Qin Q. Selection and characterization of novel DNA aptamers specifically recognized by Singapore grouper iridovirus-infected fish cells. J Gen Virol. 2015 Nov;96(11):3348-3359. doi: 10.1099/jgv.0.000270. Epub 2015 Aug 25. PMID: 26310792.

21. Wang Q, Wang S, Zhang Y, Yu Y, Zhao H, Yang H, Zheng L, Yang M, Qin Q. The CXC chemokines and CXC chemokine receptors in orange-spotted grouper (Epinephelus coioides) and their expression after Singapore grouper iridovirus infection. Dev Comp Immunol. 2019 Jan;90:10-20. doi: 10.1016/j.dci.2018.08.015. Epub 2018 Aug 27. PMID: 30165083.

22. Yang M, Jinpeng C, Wang Y, Wang Q, Wang S, Wei S, Qin Q. Nuclear factor kappa B/p65 plays a positive role in peroxisome proliferator-activated receptor δ expression in orange-spotted grouper Epinephelus coioides. Fish Shellfish Immunol. 2020 Jul;102:101-107. doi: 10.1016/j.fsi.2020.03.060. Epub 2020 Apr 4. PMID: 32259581.

23. Yu Y, Li C, Wang Y, Wang Q, Wang S, Wei S, Yang M, Qin Q. Molecular cloning and characterization of grouper Krϋppel-like factor 9 gene: Involvement in the fish immune response to viral infection. Fish Shellfish Immunol. 2019 Jun;89:677-686. doi: 10.1016/j.fsi.2019.03.041. Epub 2019 Mar 21. PMID: 30905839.

24.Yang M, Wang Y, Wang Q, Zhou Z, Yu Y, Wei S, Wang S, Qin Q. Characterization of Kruppel-like factor 6 in Epinephelus coioides: The role in viral infection and the transcriptional regulation on Peroxisome proliferator-activated receptor δ. Fish Shellfish Immunol. 2020 Apr;99:9-18. doi: 10.1016/j.fsi.2020.01.061. Epub 2020 Jan 31. PMID: 32007559.

25. Zhou L, Li P, Yang M, Yu Y, Huang Y, Wei J, Wei S, Qin Q. Generation and characterization of novel DNA aptamers against coat protein of grouper nervous necrosis virus (GNNV) with antiviral activities and delivery potential in grouper cells. Antiviral Res. 2016 May;129:104-114. doi: 10.1016/j.antiviral.2016.02.009. Epub 2016 Feb 15. PMID: 26892075.

26. Wang L, Liu C, He H, Chen J, He X, Qin Q, Yang M. Largemouth bass Rel exerts antiviral role against fish virus and regulates the expression of interleukin-10. Fish Shellfish Immunol. 2023 Sep 29:109117. doi: 10.1016/j.fsi.2023.109117. Epub ahead of print. PMID: 37778738.

27.Li P, Yang M, Ni S, Zhou L, Wang Z, Wei S, Qin Q. Complete mitochondrial genome sequence of the pelagic chaetognath, sagitta ferox. Mitochondrial DNA A DNA Mapp Seq Anal. 2016 Nov;27(6):4699-4700. doi: 10.3109/19401736.2015.1106508. Epub 2015 Dec 18. PMID: 26677727.

28. Yang M, Yang Z, Liu C, Lee X, Zhu K. Characterization of the Complete Mitochondrial Genome of the Spotted Catfish Arius maculatus (Thunberg, 1792) and Its Phylogenetic Implications. Genes (Basel). 2022 Nov 16;13(11):2128. doi: 10.3390/genes13112128. PMID: 36421803; PMCID: PMC9690425.

29. Yang M, Li P, Qin Q, Zhu K. The complete mitochondrial genome of false trevally Lactarius Lactarius (Bloch and Schneider, 1801). Mitochondrial DNA B Resour. 2019 Dec 11;5(1):87-89. doi: 10.1080/23802359.2019.1698335. PMID: 33366435; PMCID: PMC7720941.

30. Xinyue Zhang, Liqun Wang, Jiaxin Liu, Zemiao Zhang, Lingli Zhou, Xiaohong Huang, Jingguang Wei, Min Yang, Qiwei Qin, Shaowen Wang, Generation and identification of novel DNA aptamers with antiviral activities against largemouth bass virus (LMBV), Aquaculture,,2022, 547, 737478-.

31. Qing, Wang, Huirong, Yang, Min, & Yepin, et al. (2019). Toxic effects of bisphenol a on goldfish gonad development and the possible pathway of bpa disturbance in female and male fish reproduction. Chemosphere.

32. Duan, X., Liang, K., Yang, M., Zhang, M., Zuo, X., Jia, X., ... & Wang, Q. (2023). Genome-wide association study identifies candidate SNPs and genes associated with red-spotted grouper nervous necrosis virus infection of the giant grouper (Epinephelus lanceolatus). Aquaculture, 740126.

指导学生情况：

指导研究生毕业设计获优秀毕业论文，指导研究生和本科生进行暑期三下乡活动获一等奖，指导大学生创新创业活动获得省级立项